Madonna will only perform 'Like A Virgin' again for $30 million.
The '4 Minutes' star, who is set to embark on a tour this autumn, is tired of singing her early hits and has no desire to include them in her set lists.
She said: "I'm not sure I can sing 'Holiday' or 'Like A Virgin' ever again.
I just can't - unless somebody paid me like $30 million or something. Like if some Russian guy wants me to come to the wedding he's going to have to a 17-year-old, you know it."
Madonna also spoke about troubled singer Britney Spears, and revealed she works out to her new album 'Blackout'.
She added in an interview with New York radio station Z100 FM: "I actually love Britney's new album. I usually work out to her record. I do a combination of Pilates and dance aerobics.
"People need to step off. For real, let's go save her."
The 49-year-old star, who gave Justin Timberlake a vitamin injection in his butt while they were recording '4 Minutes' after he complained of a cold, insists she asked him to drop his trousers for purely professional reasons.
Madonna said: "First of all, I've seen enough butt. The reason I gave him a B-12 shot is because we only had a certain amount of days in the studio and I didn't want him to use that as a lame-a** excuse not to come to work.
"It's got nothing to do with butt. I promise you. Listen, I don't need to give him a shot to see his butt!"
Madonna denied her marriage to director Guy Ritchie is in trouble, but admitted the couple have to work hard at their relationship like everyone else.
She said: "We still have to take turns to compromise. It's not easy."